Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra

I. Alam, Zafar; M. Jenner, Andrew; E. Daniel, S.; J. Lees, A.; J. Cairns, N.; D. Marsden, C.; Jenner, Peter; Halliwell, Barry

doi:10.1046/j.1471-4159.1997.69031196.x

Public

Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra

Published in Journal of Neurochemistry • Sep 1, 1997

Authors:

Zafar I. Alam

Andrew M. Jenner

S. E. Daniel

Abstract

Oxidative damage has been implicated in the pathology of Parkinson's disease (PD), e.g., rises in the level of the DNA damage product, 8-hydroxy-2'-deoxyguanosine, have been reported. However, many other products result from oxidative DNA damage, and the pattern of products can be diagnostic of the ...

Subject

Substantia nigra

Chemistry

DNA oxidation

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