Posttranscriptional Downregulation of c-IAP2 by the Ubiquitin Protein Ligase c-IAP1 In Vivo

B. Conze, Dietrich; Albert, Lori; A. Ferrick, David; V. Goeddel, David; Yeh, Wen‐Chen; W. Mak, Tak; D. Ashwell, Jonathan

doi:10.1128/mcb.25.8.3348-3356.2005

Public

Posttranscriptional Downregulation of c-IAP2 by the Ubiquitin Protein Ligase c-IAP1 In Vivo

Published in Molecular and Cellular Biology • Mar 29, 2005

Authors:

Dietrich B. Conze

Lori Albert

David A. Ferrick

Abstract

Inhibitor of apoptosis proteins (IAPs) c-IAP1 and c-IAP2 were identified as part of the tumor necrosis factor receptor 2 (TNFR2) signaling complex and have been implicated as intermediaries in tumor necrosis factor alpha signaling. Like all RING domain-containing IAPs, c-IAP1 and c-IAP2 have ubiquit...

Subject

Ubiquitin ligase

Biology

Inhibitor of apoptosis

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