ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells

Despras, Emmanuelle; Daboussi, Fayza; Hyrien, Olivier; Marheineke, Kathrin; Kannouche, Patricia

doi:10.1093/hmg/ddq046

Public

ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells

Published in Human Molecular Genetics • Feb 1, 2010

Authors:

Emmanuelle Despras

Fayza Daboussi

Olivier Hyrien

Abstract

DNA polymerase eta (poleta) performs translesion synthesis past ultraviolet (UV) photoproducts and is deficient in cancer-prone xeroderma pigmentosum variant (XP-V) syndrome. The slight sensitivity of XP-V cells to UV is dramatically enhanced by low concentrations of caffeine. So far, the biological...

Subject

Xeroderma pigmentosum

Biology

DNA replication

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!