Impact of patatin-like phospholipase-3 (rs738409 C&gt;G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C

Trépo, Eric; Pradat, Pierre; Potthoff, Andrej; Momozawa, Yukihide; Quertinmont, Eric; Gustot, Thierry; Lemmers, Arnaud; Berthillon, Pascale; Amininejad, Leila; Chevallier, Michèle; Schlué, Jérôme; Kreipe, Hans; Devière, Jacques; P. Manns, Michael; Trépo, C.; J. Sninsky, John; Wedemeyer, Heiner; Franchimont, Denis; Moreno, Christophe

doi:10.1002/hep.24350

Public

Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C

Published in Hepatology • Apr 12, 2011

Authors:

Eric Trépo

Pierre Pradat

Andrej Potthoff

Abstract

UNLABELLED: Only 20% of patients with chronic hepatitis C (CHC) will develop cirrhosis, and fibrosis progression remains highly unpredictable. A recent genome-wide association study identified a genetic variant in the patatin-like phospholipase-3 (PNPLA3) gene (rs738409 C>G) associated with steatosi...

Subject

Steatosis

Internal medicine

Fibrosis

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