Gut Microbiota-Dependent Trimethylamine <i>N</i> -Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

Wilson Tang, W.H.; Wang, Zeneng; J. Kennedy, David; Wu, Yuping; A. Buffa, Jennifer; Agatisa-Boyle, Brendan; S. Li, Xinmin; S. Levison, Bruce; L. Hazen, Stanley

doi:10.1161/circresaha.116.305360

Public

Gut Microbiota-Dependent Trimethylamine N -Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

Published in Circulation Research • Nov 7, 2014

Authors:

W.H. Wilson Tang

Zeneng Wang

David J. Kennedy

Abstract

RATIONALE: Trimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary choline, phosphatidylcholine (lecithin), and l-carnitine, is elevated in chronic kidney diseases (CKD) and associated with coronary artery disease pathogenesis. OBJECTIVE: To both investigate the clinical progn...

Subject

Trimethylamine N-oxide

Kidney disease

Disease

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