Structure of <i>Trypanosoma cruzi</i> glycosomal glyceraldehyde‐3‐phosphate dehydrogenase complexed with chalepin, a natural product inhibitor, at 1.95 Å resolution

Pavão, Fernando; S. Castilho, Marcelo; Tallarico Pupo, Mônica; Dias, Raquel; G. Corrêa, Arlene; Batista Fernandes, João; Fátima das Graças Fernandes da Silva, Maria; Mafezoli, Jair; C. Vieira, Paulo; Oliva, Glaucius

doi:10.1016/s0014-5793(02)02700-x

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Structure of Trypanosoma cruzi glycosomal glyceraldehyde‐3‐phosphate dehydrogenase complexed with chalepin, a natural product inhibitor, at 1.95 Å resolution

Published in FEBS Letters • Apr 30, 2002

Authors:

Fernando Pavão

Marcelo S. Castilho

Mônica Tallarico Pupo

Abstract

The structure of the glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) from Trypanosoma cruzi complexed with chalepin, a natural product from Pilocarpus spicatus, has been determined by X-ray crystallography to 1.95 A resolution. The structure is in the apo form without cofactors in the s...

Subject

Trypanosoma cruzi

Stereochemistry

Chemistry

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