Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab

Gunnarsson, Martin; Malmeström, Clas; Axelsson, Markus; Sundström, Peter; Dahle, Charlotte; Vrethem, Magnus; Olsson, Tomas; Piehl, Fredrik; Norgren, Niklas; Rosengren, Lars; Svenningsson, Anders; Lycke, Jan

doi:10.1002/ana.22247

Public

Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab

Published in Annals of Neurology • Oct 29, 2010

Authors:

Martin Gunnarsson

Clas Malmeström

Markus Axelsson

Abstract

OBJECTIVE: The impact of present disease-modifying treatments (DMTs) in multiple sclerosis (MS) on nerve injury and reactive astrogliosis is still unclear. Therefore, we studied the effect of natalizumab treatment on the release of 2 brain-specific tissue damage markers into cerebrospinal fluid (CSF...

Subject

Natalizumab

Multiple sclerosis

Astrogliosis

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