Deletions Affecting Codons 557-558 of the <i>c</i>-<i>KIT</i> Gene Indicate a Poor Prognosis in Patients With Completely Resected Gastrointestinal Stromal Tumors: A Study by the Spanish Group for Sarcoma Research (GEIS)

Martín‐Broto, Javier; Poveda, Andrés; Llombart‐Bosch, Antonio; Ramos, Rafael; Antonio López‐Guerrero, José; García del Muro, Javier; Maurel, Joan; Calabuig‐Fariñas, Silvia; Gutiérrez, Antonio; L. González de Sande, José; Martínez, Javier; De Juan, Ana; Laínez, Núria; Losa, Ferrán; Alija, V.; Escudero, P.; Casado, Antonio; García, Pilar; Blanco, Remei; Buesa, J.

doi:10.1200/jco.2005.19.554

Public

Deletions Affecting Codons 557-558 of the c-KIT Gene Indicate a Poor Prognosis in Patients With Completely Resected Gastrointestinal Stromal Tumors: A Study by the Spanish Group for Sarcoma Research (GEIS)

Published in Journal of Clinical Oncology • Aug 31, 2005

Authors:

Javier Martín‐Broto

Andrés Poveda

Antonio Llombart‐Bosch

Abstract

PURPOSE: To explore the prognostic value of mutations in c-KIT and PDGFR-alpha genes with respect to relapse-free survival (RFS) in patients with gastrointestinal stromal tumors (GIST). We have investigated the prognostic relevance of the type and position of the mutations, in addition to other clin...

Subject

Medicine

Stromal cell

Gene

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