Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease

Cunningham, Colm; M. J. Deacon, Robert; Gideon Wells, H.; Boche, Delphine; Waters, Sara; Wanderley Picanço Diniz, Cristovam; E. Scott, Helen; N. P. Rawlins, J.; Hugh Perry, V.

doi:10.1046/j.1460-9568.2003.02662.x

Public

Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease

Published in European Journal of Neuroscience • May 1, 2003

Authors:

Colm Cunningham

Robert M. J. Deacon

H. Gideon Wells

Abstract

Prion diseases are fatal, chronic neurodegenerative diseases of mammals, characterized by amyloid deposition, astrogliosis, microglial activation, tissue vacuolation and neuronal loss. In the ME7 model of prion disease in the C57BL/6 J mouse, we have shown previously that these animals display behav...

Subject

Astrogliosis

Hippocampus

Biology

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