Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

A. Calin, George; Sevignani, Cinzia; Dan Dumitru, Calin; Hyslop, Terry; Noch, Evan; Yendamuri, Sai; Shimizu, Masayoshi; Rattan, Sashi; Bullrich, Florencia; Negrini, Massimo; M. Croce, Carlo

doi:10.1073/pnas.0307323101

Public

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

Published in Proceedings of the National Academy of Sciences • Feb 18, 2004

Authors:

George A. Calin

Cinzia Sevignani

Calin Dan Dumitru

Abstract

A large number of tiny noncoding RNAs have been cloned and named microRNAs (miRs). Recently, we have reported that miR-15a and miR-16a, located at 13q14, are frequently deleted and/or down-regulated in patients with B cell chronic lymphocytic leukemia, a disorder characterized by increased survival....

Subject

Chromosomal fragile site

Biology

microRNA

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