Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein.

D. Watson, A.; A Berliner, J; Hama, Susan; N. La Du, Bert; F. Faull, Kym; M. Fogelman, Alan; Navab, M.

doi:10.1172/jci118359

Public

Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein.

Published in Journal of Clinical Investigation • Dec 1, 1995

Authors:

A. D. Watson

J A Berliner

Susan Hama

Abstract

Our group has previously demonstrated that oxidized phospholipids in mildly oxidized LDL (MM-LDL) produced by oxidation with lipoxygenase, iron, or cocultures of artery wall cells increase monocyte-endothelial interactions and this sequence of events is blocked by HDL. To obtain further insight into...

Subject

Chemistry

Paraoxonase

Low-density lipoprotein

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