Recurrent Somatic<i>DICER1</i>Mutations in Nonepithelial Ovarian Cancers

Heravi‐Moussavi, Alireza; S. Anglesio, Michael; Cheng, Siwei; Senz, Janine; Yang, Winnie; Prentice, Leah; P. Fejes, Anthony; Chow, Christine; Tone, Alicia; E. Kalloger, Steve; Hamel, Nancy; Roth, Andrew; Ha, Gavin; Wan, Adrian; Maines‐Bandiera, Sarah; Salamanca, Clara; Pasini, Barbara; Clarke, Blaise; F. Lee, Anna; Lee, Cheng‐Han; Zhao, Chengquan; H. Young, Robert; Aparício, Samuel; H. Sorensen, Poul; M.M. Woo, Michelle; Boyd, Niki; J.M. Jones, Steven; Hirst, Martin; A. Marra, Marco; Blake Gilks, C.; P. Shah, Sohrab; D. Foulkes, William; B. Morin, Gregg; G. Huntsman, David

doi:10.1056/nejmoa1102903

Public

Recurrent SomaticDICER1Mutations in Nonepithelial Ovarian Cancers

Published in New England Journal of Medicine • Dec 21, 2011

Authors:

Alireza Heravi‐Moussavi

Michael S. Anglesio

Siwei Cheng

Abstract

BACKGROUND: Germline truncating mutations in DICER1, an endoribonuclease in the RNase III family that is essential for processing microRNAs, have been observed in families with the pleuropulmonary blastoma-family tumor and dysplasia syndrome. Mutation carriers are at risk for nonepithelial ovarian t...

Subject

Germline

Germline mutation

Cancer research

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