IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo

J. Jackson, David; Makrinioti, Heidi; M.J. Rana, Batika; Shamji, Betty; Trujillo‐Torralbo, Maria‐Belen; Footitt, Joseph; del-Rosario, Jerico; G. Telcian, Aurica; Nikonova, Alexandra; Zhu, Jie; Aniscenko, Julia; Gogsadze, Leila; Bakhsoliani, Eteri; Traub, Stephanie; Dhariwal, Jaideep; D. Porter, James; Hunt, Duncan; Hunt, Toby; Hunt, Trevor; Stanciu, L; Khaitov, Musa; W. Bartlett, Nathan; R. Edwards, Michael; Min Kon, Onn; Mallia, Patrick; G. Papadopoulos, Nikolaos; A. Akdiş, Cezmi; Westwick, John; Edwards, Matthew; J. Cousins, David; P. Walton, Ross; L. Johnston, Sebastian

doi:10.1164/rccm.201406-1039oc

Public

IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo

Published in American Journal of Respiratory and Critical Care Medicine • Oct 28, 2014

Authors:

David J. Jackson

Heidi Makrinioti

Batika M.J. Rana

Abstract

RATIONALE: Rhinoviruses are the major cause of asthma exacerbations; however, its underlying mechanisms are poorly understood. We hypothesized that the epithelial cell-derived cytokine IL-33 plays a central role in exacerbation pathogenesis through augmentation of type 2 inflammation. OBJECTIVES: To...

Subject

Rhinovirus

Immunology

Medicine

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