Oral Acyclovir Suppression and Neurodevelopment after Neonatal Herpes

W. Kimberlin, David; J. Whitley, Richard; Wan, Wen; A. Powell, Dwight; A. Storch, Gregory; Ahmed, Amina; Smythe Palmer, A.; J. Sánchez, Pablo; F. Jacobs, Richard; S. Bradley, John; Robinson, Joan; Shelton, Mark; H. Dennehy, Penelope; T. Leach, Charles; H. Rathore, Mobeen; Abughali, Nazha; F. Wright, Peter; M. Frenkel, Lisa; C. Brady, Rebecca; Van Dyke, Russell; B. Weiner, Leonard; A. Guzman‐Cottrill, Judith; A. McCarthy, Carol; Griffin, Jill; Jester, Penelope; Parker, Misty; D. Lakeman, Fred; Kuo, Hui‐Chien; Hyung Lee, Choo; A. Cloud, Gretchen

doi:10.1056/nejmoa1003509

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Oral Acyclovir Suppression and Neurodevelopment after Neonatal Herpes

Published in New England Journal of Medicine • Oct 5, 2011

Authors:

David W. Kimberlin

Richard J. Whitley

Wen Wan

Abstract

BACKGROUND: Poor neurodevelopmental outcomes and recurrences of cutaneous lesions remain unacceptably frequent among survivors of neonatal herpes simplex virus (HSV) disease. METHODS: We enrolled neonates with HSV disease in two parallel, identical, double-blind, placebo-controlled studies. Neonates...

Subject

Medicine

Aciclovir

Pediatrics

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