Nonsteroidal Anti-inflammatory Drugs as Anticancer Agents: Mechanistic, Pharmacologic, and Clinical Issues

J. Thun, Michael; Jane Henley, S.; Patrono, C.

doi:10.1093/jnci/94.4.252

Public

Nonsteroidal Anti-inflammatory Drugs as Anticancer Agents: Mechanistic, Pharmacologic, and Clinical Issues

Published in JNCI Journal of the National Cancer Institute • Feb 20, 2002

Authors:

Michael J. Thun

S. Jane Henley

C. Patrono

Abstract

Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 inhibitors, have promise as anticancer agents. NSAIDs restore normal apoptosis in human adenomatous colorectal polyps and in...

Subject

Medicine

Familial adenomatous polyposis

Sulindac

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