The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions.

C Antoniou, A; P Cunningham, A; Peto, J; G Evans, D; Lalloo, F; A Narod, S; A Risch, H; E Eyfjord, J; L Hopper, J; C Southey, M; Olsson, H; Johannsson, O; Borg, A; Pasini, B; Passini, B; Radice, P; Manoukian, S; M Eccles, D; Tang, N; Olah, E; Anton-Culver, H; Warner, E; Lubinski, J; Gronwald, J; Gorski, B; Tryggvadottir, L; Syrjakoski, K; Kallioniemi, O-P; Eerola, H; Nevanlinna, H; D P Pharoah, P; F Easton, D

doi:10.1038/sj.bjc.6604305

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The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions.

Published in British journal of cancer • Apr 22, 2008

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Authors:

A C Antoniou

,

A P Cunningham

,

J Peto

Abstract

Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes (polygenic component). We ...

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