Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis

H. Huang, Emina; J. Hynes, Mark; Zhang, Tao; Ginestier, Christophe; Dontu, Gabriela; D. Appelman, Henry; Z. Fields, Jeremy; S. Wicha, Max; M. Boman, Bruce

doi:10.1158/0008-5472.can-08-4418

Public

Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis

Published in Cancer Research • Apr 1, 2009

Authors:

Emina H. Huang

Mark J. Hynes

Tao Zhang

Abstract

Although the concept that cancers originate from stem cells (SC) is becoming scientifically accepted, mechanisms by which SC contribute to tumor initiation and progression are largely unknown. For colorectal cancer (CRC), investigation of this problem has been hindered by a paucity of specific marke...

Subject

Aberrant crypt foci

Carcinogenesis

CD44

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