Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach

J. Coffey, Robert; Kay Washington, M.; L. Corless, Christopher; C. Heinrich, Michael

doi:10.1172/jci30491

Public

Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach

Published in Journal of Clinical Investigation • Jan 2, 2007

Authors:

Robert J. Coffey

M. Kay Washington

Christopher L. Corless

Abstract

Ménétrier disease and gastrointestinal stromal tumors (GISTs) are hyperproliferative disorders of the stomach caused by dysregulated receptor tyrosine kinases (RTKs). In Ménétrier disease, overexpression of TGF-alpha, a ligand for the RTK EGFR, results in selective expansion of surface mucous cells ...

Subject

PDGFRA

Stomach

Receptor tyrosine kinase

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