Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

Reantragoon, Rangsima; J. Corbett, Alexandra; G. Sakala, Isaac; A. Gherardin, Nicholas; B. Furness, John; Chen, Zhenjun; B.G. Eckle, Sidonia; P. Uldrich, Adam; W. Birkinshaw, Richard; Patel, Onisha; Kostenko, Lyudmila; Meehan, Bronwyn; Kedzierska, Katherine; Liu, Ligong; P. Fairlie, David; H. Hansen, Ted; I. Godfrey, Dale; Rossjohn, Jamie; McCluskey, James; Kjer-Nielsen, Lars

doi:10.1084/jem.20130958

Public

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

Shared by NobleBlocks on Oct 7, 2013 • 12:00 AM UTC

Authors:

Rangsima Reantragoon

Alexandra J. Corbett

Isaac G. Sakala

Abstract

Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor (TCR) α-chain, TRAV1-2–TRAJ33, and are activated by vitamin B metabolites bound by the major histocompatibility complex (MHC)–related class I–like molecule, MR1. Understanding MAIT cell biology has been restra...

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