Ledipasvir and Sofosbuvir for Previously Treated HCV Genotype 1 Infection

H. Afdhal, Nezam; Rajender Reddy, K.; R. Nelson, David; Lawitz, Eric; C. Gordon, Stuart; R. Schiff, Eugene; Nahass, Ronald; Ghalib, Reem; Gitlin, Norman; Herring, Robert; Lalezari, Jacob; Younes, Ziad; J. Pockros, Paul; M. Di Bisceglie, Adrian; Arora, Sanjeev; Mani Subramanian, G.; Zhu, Yanni; Dvory‐Sobol, Hadas; C. Yang, Jenny; S. Pang, Phillip; T. Symonds, William; G. McHutchison, John; J. Muir, Andrew; Sulkowski, Mark; Y. Kwo, Paul

doi:10.1056/nejmoa1316366

Public

Ledipasvir and Sofosbuvir for Previously Treated HCV Genotype 1 Infection

Published in New England Journal of Medicine • Apr 12, 2014

Authors:

Nezam H. Afdhal

K. Rajender Reddy

David R. Nelson

Abstract

BACKGROUND: Effective treatment for hepatitis C virus (HCV) genotype 1 infection in patients who have not had a sustained virologic response to prior interferon-based therapy represents an unmet medical need. METHODS: We conducted a phase 3, randomized, open-label study involving patients infected w...

Subject

Ledipasvir

Medicine

Sofosbuvir

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