In vivo 19F Magnetic Resonance Spectroscopy and Chemical Shift Imaging of Tri-Fluoro-Nitroimidazole as a Potential Hypoxia Reporter in Solid Tumors

Procissi, Daniele; Claus, Filip; Burgman, Paul; Koziorowski, Jacek; D. Chapman, J.; B. Thakur, Sunitha; Matei, Cornelia; Ling, Charlotte; A. Koutcher, Jason

doi:10.1158/1078-0432.ccr-06-1563

Public

In vivo 19F Magnetic Resonance Spectroscopy and Chemical Shift Imaging of Tri-Fluoro-Nitroimidazole as a Potential Hypoxia Reporter in Solid Tumors

Published in Clinical Cancer Research • Jun 15, 2007

Authors:

Daniele Procissi

Filip Claus

Paul Burgman

Abstract

PURPOSE: 2-Nitro-alpha-[(2,2,2-trifluoroethoxy)methyl]-imidazole-1-ethanol (TF-MISO) was investigated as a potential noninvasive marker of tissue oxygen levels in tumors using (19)F magnetic resonance spectroscopy (MRS) and (19)F chemical shift imaging. EXPERIMENTAL DESIGNS: In vitro data were obtai...

Subject

In vivo

Tumor hypoxia

Chemistry

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