Structural Deficiencies in Granuloma Formation in TNF Gene-Targeted Mice Underlie the Heightened Susceptibility to Aerosol Mycobacterium tuberculosis Infection, Which Is Not Compensated for by Lymphotoxin

G. D. Bean, Andrew; R. Roach, Daniel; Briscoe, Helen; P. France, Malcolm; Körner, Heinrich; D. Sedgwick, Jonathon; J. Britton, Warwick

doi:10.4049/jimmunol.162.6.3504

Public

Structural Deficiencies in Granuloma Formation in TNF Gene-Targeted Mice Underlie the Heightened Susceptibility to Aerosol Mycobacterium tuberculosis Infection, Which Is Not Compensated for by Lymphotoxin

Published in The Journal of Immunology • Mar 1, 1999

Authors:

Andrew G. D. Bean

Daniel R. Roach

Helen Briscoe

Abstract

TNF and lymphotoxin-alpha (LT alpha) may act at various stages of the host response to Mycobacterium tuberculosis. To dissect the effects of TNF independent of LT alpha, we have used C57BL/6 mice with a disruption of the TNF gene alone (TNF-/-). Twenty-one days following aerosol M. tuberculosis infe...

Subject

Lymphotoxin

Tumor necrosis factor alpha

Immunology

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