Gap Junction–Mediated Import of MicroRNA from Bone Marrow Stromal Cells Can Elicit Cell Cycle Quiescence in Breast Cancer Cells

K. Lim, Philip; A. Bliss, Sarah; A. Patel, Shyam; Taborga, Marcelo; A. Dave, Meneka; A. Gregory, Larissa; J. Greco, Steven; Bryan, Margarette; Patel, Prem; Rameshwar, Pranela

doi:10.1158/0008-5472.can-10-2372

Public

Gap Junction–Mediated Import of MicroRNA from Bone Marrow Stromal Cells Can Elicit Cell Cycle Quiescence in Breast Cancer Cells

Published in Cancer Research • Feb 22, 2011

Authors:

Philip K. Lim

Sarah A. Bliss

Shyam A. Patel

Abstract

Bone marrow (BM) metastasis of breast cancer (BC) can recur even decades after initial diagnosis and treatment, implying the long-term survival of disseminated cancer cells in a dormant state. Here we investigated the role of microRNAs (miRNA) transmitted from BM stroma to BC cells via gap junctions...

Subject

Stromal cell

Microvesicles

Stroma

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