The Class I-Specific HDAC Inhibitor MS-275 Decreases Motivation to Consume Alcohol and Relapse in Heavy Drinking Rats

Jeanblanc, Jérôme; Lemoine, Sandrine; Jeanblanc, Virginie; Alaux‐Cantin, Stéphanie; Naassïla, Mickaël

doi:10.1093/ijnp/pyv029

Public

The Class I-Specific HDAC Inhibitor MS-275 Decreases Motivation to Consume Alcohol and Relapse in Heavy Drinking Rats

Published in The International Journal of Neuropsychopharmacology • Mar 11, 2015

Authors:

Jérôme Jeanblanc

Sandrine Lemoine

Virginie Jeanblanc

Abstract

BACKGROUND: New strategies for the treatment of alcohol dependence are a pressing need, and recent evidence suggests that targeting enzymes involved in epigenetic mechanisms seems to have great potential. Among these mechanisms, alteration of histone acetylation by histone deacetylases is of great i...

Subject

Nucleus accumbens

Self-administration

Ethanol

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