Uric Acid Stimulates Monocyte Chemoattractant Protein-1 Production in Vascular Smooth Muscle Cells Via Mitogen-Activated Protein Kinase and Cyclooxygenase-2

Kanellis, John; Watanabe, Susumu; Li, Jinhua; Kang, Duk‐Hee; Li, Ping; Nakagawa, Takahiko; Wamsley, Ann; Sheikh‐Hamad, David; Y. Lan, Hui; Feng, Lili; J. Johnson, Richard

doi:10.1161/01.hyp.0000072820.07472.3b

Public

Uric Acid Stimulates Monocyte Chemoattractant Protein-1 Production in Vascular Smooth Muscle Cells Via Mitogen-Activated Protein Kinase and Cyclooxygenase-2

Published in Hypertension • May 13, 2003

Authors:

John Kanellis

Susumu Watanabe

Jinhua Li

Abstract

Previous studies have reported that uric acid stimulates vascular smooth muscle cell (VSMC) proliferation in vitro. We hypothesized that uric acid may also have direct proinflammatory effects on VSMCs. Crystal- and endotoxin-free uric acid was found to increase VSMC monocyte chemoattractant protein-...

Subject

Proinflammatory cytokine

Uric acid

Vascular smooth muscle

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