Decreased Cancer Risk After Iron Reduction in Patients With Peripheral Arterial Disease: Results From a Randomized Trial

R. Zacharski, L.; K. Chow, Bruce; S. Howes, Paula; Shamayeva, Galina; A. Baron, J.; L. Dalman, Ronald; J. Malenka, David; Keith Ozaki, C.; W. Lavori, Phillip

doi:10.1093/jnci/djn209

Public

Decreased Cancer Risk After Iron Reduction in Patients With Peripheral Arterial Disease: Results From a Randomized Trial

Published in JNCI Journal of the National Cancer Institute • Jul 8, 2008

Authors:

L. R. Zacharski

Bruce K. Chow

Paula S. Howes

Abstract

BACKGROUND: Excess iron has been implicated in cancer risk through increased iron-catalyzed free radical-mediated oxidative stress. METHODS: A multicenter randomized, controlled, single-blinded clinical trial (VA Cooperative Study #410) tested the hypothesis that reducing iron stores by phlebotomy w...

Subject

Peripheral

Oxidative stress

Cancer

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