The Role of Mitochondrial DNA Copy Number in Mammalian Fertility1

Wai, Timothy; Ao, Asangla; Zhang, Xiaoyun; G. Cyr, Daniel; Dufort, Daniel; A. Shoubridge, Eric

doi:10.1095/biolreprod.109.080887

Public

The Role of Mitochondrial DNA Copy Number in Mammalian Fertility1

Published in Biology of Reproduction • Feb 3, 2010

Authors:

Timothy Wai

Asangla Ao

Xiaoyun Zhang

Abstract

Mammalian mitochondrial DNA (mtDNA) is a small, maternally inherited genome that codes for 13 essential proteins in the respiratory chain. Mature oocytes contain more than 150 000 copies of mtDNA, at least an order of magnitude greater than the number in most somatic cells, but sperm contain only ap...

Subject

TFAM

Biology

Mitochondrial DNA

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