Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

Chalmin, Fanny; Ladoire, Sylvain; Mignot, Grégoire; Vincent, Julie; Bruchard, Mélanie; Rémy-Martin, Jean-Paul; Boireau, Wilfrid; Rouleau, Alain; Simon, B.; Lanneau, David; de Thonel, Aurélie; Multhoff, Gabriele; Hamman, Arlette; Martin, François; Chauffert, Bruno; Solary, Éric; Zitvogel, Laurence; Garrido, Carmen; Ryffel, Bernhard; Borg, Christophe; Apétoh, Lionel; Rébé, Cédric; Ghiringhelli, François

doi:10.1172/jci40483

Public

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

Published in Journal of Clinical Investigation • Jan 19, 2010

Authors:

Fanny Chalmin

Sylvain Ladoire

Grégoire Mignot

Abstract

Myeloid-derived suppressor cells (MDSCs) have been identified in humans and mice as a population of immature myeloid cells with the ability to suppress T cell activation. They accumulate in tumor-bearing mice and humans and have been shown to contribute to cancer development. Here, we have isolated ...

Subject

Myeloid-derived Suppressor Cell

Microvesicles

Suppressor

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