Rifampin and pyrazinamide vs isoniazid for prevention of tuberculosis in HIV-infected persons: an international randomized trial. Terry Beirn Community Programs for Clinical Research on AIDS, the Adult AIDS Clinical Trials Group, the Pan American Health Organization, and the Centers for Disease Control and Prevention Study Group.

Gordin, F; E Chaisson, R; P Matts, J; Miller, C; de Lourdes Garcia, M; Hafner, R; L Valdespino, J; Coberly, J; Schechter, M; J Klukowicz, A; A Barry, M; J O'Brien, R

doi:10.1001/jama.283.11.1445

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Rifampin and pyrazinamide vs isoniazid for prevention of tuberculosis in HIV-infected persons: an international randomized trial. Terry Beirn Community Programs for Clinical Research on AIDS, the Adult AIDS Clinical Trials Group, the Pan American Health Organization, and the Centers for Disease Control and Prevention Study Group.

Shared by NobleBlocks on Mar 15, 2000 • 12:00 AM UTC

Authors:

F Gordin

R E Chaisson

J P Matts

Abstract

CONTEXT: Because of problems with adherence, toxicity, and increasing resistance associated with 6- to 12-month isoniazid regimens, an alternative short-course tuberculosis preventive regimen is needed. OBJECTIVE: To compare a 2-month regimen of daily rifampin and pyrazinamide with a 12-month regime...

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