The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

Greenhough, Alexander; Smartt, H; E. Moore, Alice; R Roberts, H; C. Williams, Ann; Paraskeva, Christos; Kaidi, Abderrahmane

doi:10.1093/carcin/bgp014

Public

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

Published in Carcinogenesis • Jan 9, 2009

Authors:

Alexander Greenhough

H Smartt

Alice E. Moore

Abstract

It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the abundance of its enzymatic product prostaglandin E(2) (PGE(2)) have key roles in influencing the development of colorectal cancer. Deregulation of the COX-2/PGE(2) pathway appears to affect colorectal tumorigenesis...

Subject

Carcinogenesis

Cellular adaptation

Cancer research

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