A Recombinant Vesicular Stomatitis Virus Ebola Vaccine

A. Regules, Jason; H. Beigel, John; Paolino, Kristopher; Voell, Jocelyn; R. Castellano, Amy; Hu, Zonghui; Rubio Muñoz, P.; E. Moon, James; C. Ruck, Richard; W. Bennett, Jason; Twomey, Patrick; L. Gutiérrez, Ramiro; Remich, Shon; R. Hack, Holly; L. Wisniewski, Meagan; Josleyn, Matthew; A. Kwilas, Steven; Van Deusen, Nicole; Tshiani Mbaya, Olivier; Zhou, Yan; A. Stanley, Daphne; Wang, Jing; S. Smith, Kirsten; Shi, Meng; E. Ledgerwood, Julie; S. Graham, Barney; J. Sullivan, Nancy; L. Jagodzinski, Linda; A. Peel, Sheila; B. Alimonti, Judie; W. Hooper, Jay; Silvera, Peter; K. Martin, Brian; P. Monath, Thomas; Jay Ramsey, W.; J. Link, Charles; Clifford Lane, H.; L. Michael, Nelson; T. Davey, Richard; J. Thomas, Stephen

doi:10.1056/nejmoa1414216

Public

A Recombinant Vesicular Stomatitis Virus Ebola Vaccine

Published in New England Journal of Medicine • Apr 2, 2015

Authors:

Jason A. Regules

John H. Beigel

Kristopher Paolino

Abstract

BACKGROUND: The worst Ebola virus disease (EVD) outbreak in history has resulted in more than 28,000 cases and 11,000 deaths. We present the final results of two phase 1 trials of an attenuated, replication-competent, recombinant vesicular stomatitis virus (rVSV)-based vaccine candidate designed to ...

Subject

Vesicular stomatitis virus

Ebola virus

Virology

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