KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer

Loupakis, Fotios; Ruzzo, Annamaria; Cremolini, Chiara; Vincenzi, Bruno; Salvatore, Lisa; Santini, Daniele; Masi, Gianluca; Stasi, I.; Canestrari, Emanuele; Rulli, Eliana; Floriani, Irene; Bencardino, Katia; Galluccio, Nadia; Catalano, Vincenzo; Tonini, Giuseppe; Magnani, Mauro; Fontanini, Gabriella; Basolo, Fulvio; Falcone, Alfredo; Graziano, Francesco

doi:10.1038/sj.bjc.6605177

Public

KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer

Published in British Journal of Cancer • Jul 14, 2009

Authors:

Fotios Loupakis

Annamaria Ruzzo

Chiara Cremolini

Abstract

BACKGROUND: KRAS codons 12 and 13 mutations predict resistance to anti-EGFR monoclonal antibodies (moAbs) in metastatic colorectal cancer. Also, BRAF V600E mutation has been associated with resistance. Additional KRAS mutations are described in CRC. METHODS: We investigated the role of KRAS codons 6...

Subject

KRAS

Cetuximab

Colorectal cancer

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