Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium

Bastide, Pauline; Darido, Charbel; Pannequin, Julie; Kist, Ralf; Robine, Sylvie; Marty-Double, C; Bibeau, Frédéric; Scherer, Gerd; Joubert, Dominique; Hollande, Frédéric; Blache, Philippe; Jay, Philippe

doi:10.1083/jcb.200704152

Public

Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium

Published in The Journal of Cell Biology • Aug 13, 2007

Authors:

Pauline Bastide

Charbel Darido

Julie Pannequin

Abstract

The HMG-box transcription factor Sox9 is expressed in the intestinal epithelium, specifically, in stem/progenitor cells and in Paneth cells. Sox9 expression requires an active beta-catenin-Tcf complex, the transcriptional effector of the Wnt pathway. This pathway is critical for numerous aspects of ...

Subject

Biology

Intestinal epithelium

Wnt signaling pathway

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!