Prevention of HIV-1 Infection with Early Antiretroviral Therapy

S. Cohen, Myron; Qing Chen, Ying; McCauley, Marybeth; Gamble, Theresa; C. Hosseinipour, Mina; Kumarasamy, Nagalingeswaran; Hakim, James; Kumwenda, Johnstone; Grinsztejn, Beatriz; Henrique Pilotto, José; Godbole, Sheela; Mehendale, Sanjay; Chariyalertsak, Suwat; Santos, Breno; H. Mayer, Kenneth; Hoffman, Irving; H. Eshleman, Susan; Piwowar‐Manning, Estelle; Wang, Lei; Makhema, Joseph; Mills, Lisa; de Bruyn, Guy; Sanne, Ian; J. Eron, Joseph; E. Gallant, Joel; V. Havlir, Diane; Swindells, Susan; J. Ribaudo, Heather; Elharrar, Vanessa; Burns, David; E. Taha, Taha; Nielsen‐Saines, Karin; D. Celentano, David; Essex, Max; R. Fleming, Thomas

doi:10.1056/nejmoa1105243

Public

Prevention of HIV-1 Infection with Early Antiretroviral Therapy

Published in New England Journal of Medicine • Jul 18, 2011

Authors:

Myron S. Cohen

Ying Qing Chen

Marybeth McCauley

Abstract

BACKGROUND: Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. METHODS: In nine countries, we enrolled 1763 couples in which one partner was HIV-1-positive and the other was HIV-1-negative; 54% ...

Subject

Medicine

Hazard ratio

Serodiscordant

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