Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

Xin, Hongqi; Li, Yi; Cui, Yisheng; J. Yang, James; Gang Zhang, Zheng; Chopp, Michael

doi:10.1038/jcbfm.2013.152

Public

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

Published in Journal of Cerebral Blood Flow & Metabolism • Aug 21, 2013

Authors:

Hongqi Xin

Yi Li

Yisheng Cui

Abstract

Here, for the first time, we test a novel hypothesis that systemic treatment of stroke with exosomes derived from multipotent mesenchymal stromal cells (MSCs) promote neurovascular remodeling and functional recovery after stroke in rats. Adult male Wistar rats were subjected to 2 hours of middle cer...

Subject

Microvesicles

Mesenchymal stem cell

Neurovascular bundle

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