Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

Wu, Beili; Y. T. Chien, Ellen; D. Mol, Clifford; Fenalti, Gustavo; Liu, Wei; Katritch, Vsevolod; Abagyan, Ruben; Brooun, Alexei; G. Wells, Peter; Christopher Bi, F.; J. Hamel, Damon; Kühn, Peter; M. Handel, Tracy; Cherezov, Vadim; C. Stevens, Raymond

doi:10.1126/science.1194396

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Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

Published in Science • Oct 7, 2010

Authors:

Beili Wu

Ellen Y. T. Chien

Clifford D. Mol

Abstract

Chemokine receptors are critical regulators of cell migration in the context of immune surveillance, inflammation, and development. The G protein-coupled chemokine receptor CXCR4 is specifically implicated in cancer metastasis and HIV-1 infection. Here we report five independent crystal structures o...

Subject

G protein-coupled receptor

Chemokine receptor

Chemokine

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