Obstructive Sleep Apnea Syndrome Affects Liver Histology and Inflammatory Cell Activation in Pediatric Nonalcoholic Fatty Liver Disease, Regardless of Obesity/Insulin Resistance

Nobili, Valério; Cutrera, Renato; Liccardo, Daniela; Pavone, Martino; De Vito, Rita; Giorgio, Valentina; Verrillo, Elisabetta; Baviera, Giuseppe; Musso, Giovanni

doi:10.1164/rccm.201307-1339oc

Public

Obstructive Sleep Apnea Syndrome Affects Liver Histology and Inflammatory Cell Activation in Pediatric Nonalcoholic Fatty Liver Disease, Regardless of Obesity/Insulin Resistance

Published in American Journal of Respiratory and Critical Care Medicine • Nov 20, 2013

Authors:

Valério Nobili

Renato Cutrera

Daniela Liccardo

Abstract

RATIONALE: Obstructive sleep apnea syndrome (OSAS) and nonalcoholic fatty liver disease (NAFLD) are frequently encountered in obese children. Whether OSAS and intermittent hypoxia are associated with liver injury in pediatric NAFLD is unknown. OBJECTIVES: To assess the relationship of OSAS with live...

Subject

Medicine

Nonalcoholic fatty liver disease

Insulin resistance

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