Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer

J. Gradishar, William; Tjulandin, Sergei; Davidson, Neville; Shaw, Heather; Desai, Neil; Bhar, Paul; Hawkins, Michael; O'Shaughnessy, Joyce

doi:10.1200/jco.2005.04.937

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Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer

Shared by NobleBlocks on Nov 1, 2005 • 12:00 AM UTC

Authors:

William J. Gradishar

Sergei Tjulandin

Neville Davidson

Abstract

Purpose ABI-007, the first biologically interactive albumin-bound paclitaxel in a nanameter particle, free of solvents, was compared with polyethylated castor oil–based standard paclitaxel in patients with metastatic breast cancer (MBC). This phase III study was performed to confirm preclinical stud...

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