Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer

J. Gradishar, William; Tjulandin, Sergei; Davidson, Neville; Shaw, Heather; Desai, Neil; Bhar, Paul; Hawkins, Michael; O’Shaughnessy, Joyce

doi:10.1200/jco.2005.04.937

Public

Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer

Published in Journal of Clinical Oncology • Sep 19, 2005

Authors:

William J. Gradishar

Sergei Tjulandin

Neville Davidson

Abstract

PURPOSE: ABI-007, the first biologically interactive albumin-bound paclitaxel in a nanameter particle, free of solvents, was compared with polyethylated castor oil-based standard paclitaxel in patients with metastatic breast cancer (MBC). This phase III study was performed to confirm preclinical stu...

Subject

Medicine

Paclitaxel

Premedication

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