Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

C. Kujoth, Gregory; Hiona, Asimina; D. Pugh, Thomas; Someya, Shinichi; Panzer, K.; E. Wohlgemuth, Stephanie; Hofer, Tim; Y. Seo, Arnold; Sullivan, Rachel; A. Jobling, Wendy; D. Morrow, Jason; Van Remmen, Holly; M. Sedivy, John; Yamasoba, Tatsuya; Tanokura, Masaru; Weindruch, Richard; Leeuwenburgh, Christiaan; A. Prolla, Tomas

doi:10.1126/science.1112125

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Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

Published in Science • Jul 14, 2005

Authors:

Gregory C. Kujoth

Asimina Hiona

Thomas D. Pugh

Abstract

Mutations in mitochondrial DNA (mtDNA) accumulate in tissues of mammalian species and have been hypothesized to contribute to aging. We show that mice expressing a proofreading-deficient version of the mitochondrial DNA polymerase g (POLG) accumulate mtDNA mutations and display features of accelerat...

Subject

Mitochondrial DNA

Biology

Oxidative stress

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