Dectin-1 Interaction with <i>Mycobacterium tuberculosis</i> Leads to Enhanced IL-12p40 Production by Splenic Dendritic Cells

Gigliotti Rothfuchs, Antonio; Báfica, André; G. Feng, Carl; G. Egen, Jackson; L. Williams, David; D. Brown, Gordon; Sher, Alan

doi:10.4049/jimmunol.179.6.3463

Public

Dectin-1 Interaction with Mycobacterium tuberculosis Leads to Enhanced IL-12p40 Production by Splenic Dendritic Cells

Published in The Journal of Immunology • Sep 1, 2007

Authors:

Antonio Gigliotti Rothfuchs

André Báfica

Carl G. Feng

Abstract

Dectin-1 is a fungal pattern recognition receptor that binds to beta-glucans and triggers cytokine production by facilitating interaction with TLR2 or by directly activating spleen tyrosine kinase (Syk). To assess the possible role of Dectin-1 in the innate response to mycobacteria, we used an in vi...

Subject

Mycobacterium tuberculosis

Microbiology

Mycobacterium

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