Effects of Substituents in the β-Position of 1,3-Dicarbonyl Compounds in Bromodimethylsulfonium Bromide-Catalyzed Multicomponent Reactions: A Facile Access to Functionalized Piperidines

T. Khan, Abu; Parvin, Tasneem; H. Choudhury, Lokman

doi:10.1021/jo8014962

Public

Effects of Substituents in the β-Position of 1,3-Dicarbonyl Compounds in Bromodimethylsulfonium Bromide-Catalyzed Multicomponent Reactions: A Facile Access to Functionalized Piperidines

Published in The Journal of Organic Chemistry • Oct 8, 2008

Authors:

Abu T. Khan

Tasneem Parvin

Lokman H. Choudhury

Abstract

1,3-Dicarbonyl compounds can be converted to Mannich-type products A or highly functionalized piperidines B in the presence of a catalytic amount of bromodimethylsulfonium bromide (BDMS). The combination of aromatic aldehyde, amine, and 1,3-dicarbonyl compounds in the presence of a catalytic amount ...

Subject

Aldehyde

Catalysis

Amine gas treating

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