Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trial

Haque, Tanzina; Wilkie, Gwen; M. Jones, Marie; Higgins, Craig; E. D. Urquhart, G.; J Wingate, Phoebe; Burns, David; A. McAulay, Karen; Turner, Marc; Bellamy, Christopher; L Amlot, P; Kelly, Déirdre; MacGilchrist, Alastair; K. Gandhi, Maher; J. Swerdlow, Anthony; H. Crawford, Dorothy

doi:10.1182/blood-2006-12-063008

Public

Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trial

Published in Blood • Apr 28, 2007

Authors:

Tanzina Haque

Gwen Wilkie

Marie M. Jones

Abstract

We present the results of a multicenter clinical trial using Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes (CTLs) generated from EBV-seropositive blood donors to treat patients with EBV-positive posttransplantation lymphoproliferative disease (PTLD) on the basis of the best HLA match and...

Subject

Medicine

CTL*

Cytotoxic T cell

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