IRF8 mutations and human dendritic-cell immunodeficiency.

S, Hambleton; S, Salem; J, Bustamante; V, Bigley; S, Boisson-Dupuis; J, Azevedo; A, Fortin; M, Haniffa; L, Ceron-Gutierrez; CM, Bacon; G, Menon; C, Trouillet; D, McDonald; P, Carey; F, Ginhoux; L, Alsina; TJ, Zumwalt; XF, Kong; D, Kumararatne; K, Butler; M, Hubeau; J, Feinberg; S, Al-Muhsen; A, Cant; L, Abel; D, Chaussabel; R, Doffinger; E, Talesnik; A, Grumach; A, Duarte; K, Abarca; D, Moraes-Vasconcelos; D, Burk; A, Berghuis; F, Geissmann; M, Collin; JL, Casanova; P, Gros

doi:10.1056/nejmoa1100066

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IRF8 mutations and human dendritic-cell immunodeficiency.

Shared by NobleBlocks on Apr 27, 2011 • 12:00 AM UTC

Authors:

Hambleton S

Salem S

Bustamante J

Abstract

Background The genetic analysis of human primary immunodeficiencies has defined the contribution of specific cell populations and molecular pathways in the host defense against infection. Disseminated infection caused by bacille Calmette-Guérin (BCG) vaccines is an early manifestation of primary imm...

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