IRF8 Mutations and Human Dendritic-Cell Immunodeficiency

Hambleton, Sophie; Salem, Sandra; Bustamante, Jacinta; Bigley, Venetia; Boisson‐Dupuis, Stéphanie; Azevedo, Joana; Fortin, Anny; Haniffa, Muzlifah; Ceron‐Gutierrez, Lourdes; M. Bacon, Chris; Menon, Geetha; Trouillet, Céline; McDonald, David; Carey, Peter; Ginhoux, Florent; Alsina, Laia; J. Zumwalt, Timothy; Kong, Xiao‐Fei; Kumararatne, Dinakantha; Butler, Karina; Hubeau, Marjorie; Feinberg, Jacqueline; Al‐Muhsen, Saleh; J. Cant, Andrew; Abel, Laurent; Chaussabel, Damien; Döffinger, Rainer; Talesnik, Eduardo; Sevciovic Grumach, Anete; José da Silva Duarte, Alberto; Abarca, Katia; de Moraes Vasconcelos, Dewton; L. Burk, David; M. Berghuis, Albert; Geissmann, Frédéric; Collin, Matthew; Casanova, Jean‐Laurent; Gros, Philippe

doi:10.1056/nejmoa1100066

Public

IRF8 Mutations and Human Dendritic-Cell Immunodeficiency

Published in New England Journal of Medicine • Apr 27, 2011

Authors:

Sophie Hambleton

Sandra Salem

Jacinta Bustamante

Abstract

BACKGROUND: The genetic analysis of human primary immunodeficiencies has defined the contribution of specific cell populations and molecular pathways in the host defense against infection. Disseminated infection caused by bacille Calmette-Guérin (BCG) vaccines is an early manifestation of primary im...

Subject

Primary immunodeficiency

Severe combined immunodeficiency

Medicine

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