Localization of a Breast Cancer Susceptibility Gene, <i>BRCA2</i> , to Chromosome 13q12-13

Wooster, Richard; L. Neuhausen, Susan; Mangion, Jonathan; Quirk, Yvette; Ford, Deborah; Collins, Nadine; Nguyễn, Kim; Seal, Sheila; Tran, Thao; Averill, D.; Fields, Patty; Marshall, Gill; A. Narod, Steven; Lenoir, Gilbert; T. Lynch, Henry; Feunteun, Jean; Devilee, Peter; J. Cornelisse, Cees; H. Menko, Fred; A. Daly, Peter; Ormiston, W.; McManus, Ross; Pye, Carole; M. Lewis, Cathryn; Cannon‐Albright, Lisa; Peto, Julian; A.J. Ponder, Bruce; H. Skolnick, Mark; F. Easton, Douglas; E. Goldgar, David; R. Stratton, Michael

doi:10.1126/science.8091231

Public

Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13

Published in Science • Sep 30, 1994

Authors:

Richard Wooster

Susan L. Neuhausen

Jonathan Mangion

Abstract

A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 loc...

Subject

Breast cancer

Centimorgan

Locus (genetics)

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