Long Noncoding RNA <i>MRUL</i> Promotes <i>ABCB1</i> Expression in Multidrug-Resistant Gastric Cancer Cell Sublines

Wang, Ying; Zhang, Dexin; Wu, Kaichun; Zhao, Qingchuan; Nie, Yongzhan; Fan, Daiming

doi:10.1128/mcb.01580-13

Public

Long Noncoding RNA MRUL Promotes ABCB1 Expression in Multidrug-Resistant Gastric Cancer Cell Sublines

Published in Molecular and Cellular Biology • Jun 24, 2014

Authors:

Ying Wang

Dexin Zhang

Kaichun Wu

Abstract

Multidrug resistance (MDR) is the most common cause of chemotherapy failure in gastric cancer (GC) treatment; however, the underlying molecular mechanisms remain elusive. Long noncoding RNAs (lncRNAs) can be involved in carcinogenesis, but the effects of lncRNAs on MDR are poorly understood. We show...

Subject

Biology

Multiple drug resistance

Gene knockdown

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