Common Genetic Variation and the Control of HIV-1 in Humans

Fellay, Jacques; Ge, Dongliang; V. Shianna, Kevin; Colombo, Sara; Ledergerber, Bruno; T. Cirulli, Elizabeth; Urban, Thomas; Zhang, Kunlin; Gumbs, Curtis; P. Smith, Jason; Castagna, Antonella; Cozzi‐Lepri, Alessandro; De Luca, Andrea; Easterbrook, Philippa; F. Günthard, Huldrych; Mallal, S.; Mussini, Cristina; Dalmau, Judith; Martínez‐Picado, Javier; M. Miró, José; Obel, Niels; M. Wolinsky, Steven; Martinson, Jeremy; Detels, Roger; B. Margolick, Joseph; P. Jacobson, Lisa; Descombes, Patrick; E. Antonarakis, Stylianos; Beckmann, J.; J. O’Brien, Stephen; L. Letvin, Norman; J. McMichael, Andrew; F. Haynes, Barton; Carrington, Mary; Feng, Sheng; Telenti, Amalio; B. Goldstein, David

doi:10.1371/journal.pgen.1000791

Public

Common Genetic Variation and the Control of HIV-1 in Humans

Published in PLoS Genetics • Dec 23, 2009

Authors:

Jacques Fellay

Dongliang Ge

Kevin V. Shianna

Abstract

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We ...

Subject

Biology

Genetics

Genetic variation

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