HDAC4 controls histone methylation in response to elevated cardiac load

Hohl, Mathias; Wagner, Michael; Reil, Jan‐Christian; Müller, Sarah-Anne; Tauchnitz, Marcus; Zimmer, A.; Lehmann, Lorenz; Thiel, Gerald; Böhm, Michael; Backs, Johannes; Maack, Christoph

doi:10.1172/jci61084

Public

HDAC4 controls histone methylation in response to elevated cardiac load

Published in Journal of Clinical Investigation • Feb 21, 2013

Authors:

Mathias Hohl

Michael Wagner

Jan‐Christian Reil

Abstract

In patients with heart failure, reactivation of a fetal gene program, including atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), is a hallmark for maladaptive remodeling of the LV. The mechanisms that regulate this reactivation are incompletely understood. Histone acetylation an...

Subject

HDAC4

Histone

Epigenetics

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