Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle Cells

Eguchi, Satoru; Numaguchi, Kotaro; Iwasaki, Hiroaki; Matsumoto, Takeshi; Yamakawa, Tadashi; Utsunomiya, Hirotoshi; D. Motley, Evangeline; Kawakatsu, Hisaaki; Owada, Koji; Hirata, Yukio; Marumo, Fumiaki; Inagami, Tadashi

doi:10.1074/jbc.273.15.8890

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Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle Cells

Published in Journal of Biological Chemistry • Apr 1, 1998

Authors:

Satoru Eguchi

Kotaro Numaguchi

Hiroaki Iwasaki

Abstract

We have recently reported that angiotensin II (Ang II)-induced mitogen-activated protein kinase (MAPK) activation is mainly mediated by Ca2+-dependent activation of a protein tyrosine kinase through Gq-coupled Ang II type 1 receptor in cultured rat vascular smooth muscle cells (VSMC). In the present...

Subject

Transactivation

Vascular smooth muscle

Chemistry

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