A Dose-Escalation Study of Weekly Topotecan, Cisplatin, and Gemcitabine Front-Line Therapy in Patients with Inoperable Non-Small Cell Lung Cancer

J. Guarino, Michael; Schneider, Charles; S. Grubbs, Stephen; D. Biggs, David; L. Himelstein, Andrew; Hogaboom, Kurt; Tilak, Samir

doi:10.1634/theoncologist.7-6-509

Public

A Dose-Escalation Study of Weekly Topotecan, Cisplatin, and Gemcitabine Front-Line Therapy in Patients with Inoperable Non-Small Cell Lung Cancer

Published in The Oncologist • Dec 1, 2002

Authors:

Michael J. Guarino

Charles Schneider

Stephen S. Grubbs

Abstract

PURPOSE: To determine the optimal dose of combination topotecan, cisplatin, and gemcitabine in advanced non-small cell lung cancer patients. MATERIALS AND METHODS: This single-center, single-practice, phase I trial enrolled chemotherapy-naïve patients with inoperable stage IIIB/IV disease. Initial t...

Subject

Medicine

Topotecan

Gemcitabine

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