Peroxiredoxin 1 knockdown potentiates -lapachone cytotoxicity through modulation of reactive oxygen species and mitogen-activated protein kinase signals

He, Tiantian; Banach-Latapy, Agata; Vernis, Laurence; Dardalhon, M.; Chanet, R.; Huang, Meng‐Er

doi:10.1093/carcin/bgs389

Public

Peroxiredoxin 1 knockdown potentiates -lapachone cytotoxicity through modulation of reactive oxygen species and mitogen-activated protein kinase signals

Published in Carcinogenesis • Dec 13, 2012

Authors:

Tiantian He

Agata Banach-Latapy

Laurence Vernis

Abstract

Peroxiredoxin (Prx) 1 is a member of the thiol-specific peroxidases family and plays diverse roles such as H2O2 scavenger, redox signal transducer and molecular chaperone. Prx1 has been reported to be involved in protecting cancer cells against various therapeutic challenges. We investigated how mod...

Subject

Gene knockdown

Peroxiredoxin

Reactive oxygen species

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